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flag 49ers rookie running back Isaac Guerendo suffers season-ending knee and ankle injury.

flag Rookie 49ers running back Isaac Guerendo suffered a serious knee and ankle injury early in their game against the Arizona Cardinals, ruling him out for the remainder of the season. flag Guerendo had shown promise with 415 yards and four touchdowns this season. flag His injury could affect the team's future decisions on free agents and potential draft picks for the backfield.

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