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Researchers find tumor stiffness promotes cancer growth, suggesting new treatment targets.
Researchers at Texas A&M University found that stiffening of tumor tissue promotes cancer cell growth by affecting the nucleus.
In a stiff environment, the nuclear lamina becomes unwrinkled, allowing YAP protein to enter the nucleus and increase cell proliferation.
This discovery suggests new cancer treatments could target tumor stiffness, focusing on proteins like lamin A/C.
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Los investigadores encuentran que la rigidez tumoral promueve el crecimiento del cáncer, sugiriendo nuevos objetivos de tratamiento.