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Study reveals how HER2 and αVβ6 integrin proteins work together in aggressive breast cancer, leading to drug resistance.
Researchers identified a mechanism in aggressive HER2-positive breast cancer where two proteins, HER2 and αVβ6 integrin, collaborate to drive cancer cell invasion and drug resistance.
This interaction is disrupted in cells resistant to trastuzumab, a common treatment, offering insights into treatment failure.
The study suggests potential new therapeutic targets and biomarkers for predicting treatment outcomes.
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El estudio revela cómo las proteínas integradoras HER2 y αVβ6 trabajan juntas en el cáncer de mama agresivo, lo que conduce a la resistencia a los fármacos.