Study reveals how HER2 and αVβ6 integrin proteins work together in aggressive breast cancer, leading to drug resistance.

Researchers identified a mechanism in aggressive HER2-positive breast cancer where two proteins, HER2 and αVβ6 integrin, collaborate to drive cancer cell invasion and drug resistance. This interaction is disrupted in cells resistant to trastuzumab, a common treatment, offering insights into treatment failure. The study suggests potential new therapeutic targets and biomarkers for predicting treatment outcomes.

4 months ago
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