FDA rejects govorestat for treating Classic Galactosemia, a rare disease, citing application deficiencies.

The FDA has issued a Complete Response Letter for govorestat, a potential treatment for Classic Galactosemia, a rare genetic disease affecting about 3,300 patients in the USA. The drug showed promise in clinical trials but faced deficiencies in its application. Applied Therapeutics, the drug's developer, plans to review the feedback and seek a meeting to discuss next steps, including potential resubmission or appeal. The company’s stock dropped significantly following the FDA’s decision.

November 27, 2024
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