Akero Therapeutics' drug EFX shows promise in reversing liver disease in patients with MASH.

Akero Therapeutics has revealed promising results from its HARMONY study, showing that efruxifermin (EFX) can reverse disease in patients with pre-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH). After 96 weeks, more than 40% of patients treated with EFX 50mg showed improved fibrosis and better liver health markers, compared to 0% on placebo. The drug also led to clinically meaningful reductions in liver stiffness and fibrosis biomarkers in over 50% of treated patients. These findings suggest EFX could be a significant new therapy for MASH.

November 15, 2024
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