UCLA researchers discovered that F-actin hampers cellular waste removal, contributing to brain aging and cognitive decline.

UCLA researchers found that the protein filamentous actin (F-actin) contributes to brain aging by inhibiting the removal of cellular waste, leading to cognitive decline. By modifying genes in aging fruit flies, they prevented F-actin buildup, enhanced cellular recycling, and increased lifespan by about 30%. This suggests that targeting F-actin could improve aging and cognitive health, potentially informing future treatments for age-related diseases in humans.

October 28, 2024
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