Epicrispr reveals epigenetic therapy EPI-321 for FSHD, targeting D4Z4 region in early 2025 clinical trials.

Epicrispr Biotechnologies showcased its epigenetic editing platform and data for its therapy EPI-321 aimed at treating facioscapulohumeral muscular dystrophy (FSHD) at the ESGCT Congress. The new epigenetic modulator can reactivate a silenced gene to nearly 100% expression for over 75 days. Epicrispr plans to start clinical trials for EPI-321 in early 2025, targeting the D4Z4 region on chromosome 4 to inhibit harmful DUX4 gene expression.

October 22, 2024
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