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Researchers discovered biomarkers for immunotherapy success prediction in liver cancer, highlighting the role of NBR1 and potential therapeutic strategies.
Researchers at Weill Cornell Medicine have identified biomarkers for predicting immunotherapy success in liver cancer (hepatocellular carcinoma).
Their study, published in Molecular Cell, highlights the role of the protein NBR1 in hepatic stellate cells.
High NBR1 levels may indicate poor immunotherapy response.
Strategies to lower NBR1 showed tumor-shrinking effects in animal models, suggesting new therapeutic avenues for patients who do not respond to existing treatments.
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Los investigadores descubrieron biomarcadores para la predicción del éxito de la inmunoterapia en el cáncer de hígado, destacando el papel de NBR1 y las estrategias terapéuticas potenciales.