University of Virginia research suggests the "fight or flight" response worsens C. diff infections, targeting alpha 2 adrenergic receptors for potential treatments.

Research from the University of Virginia School of Medicine indicates that the "fight or flight" response may worsen Clostridioides difficile (C. diff) infections, which affect about 500,000 Americans yearly and lead to roughly 30,000 deaths. The study highlights the alpha 2 adrenergic receptor as a target for potential treatments to mitigate infection severity by calming the nervous system's response. This work, funded by the National Institutes of Health, was published in Cell Reports Medicine.

October 10, 2024
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