5-FU chemotherapy drug kills gastrointestinal cancer cells via RNA synthesis interference, not DNA damage.

A study from MIT reveals that the chemotherapy drug 5-fluorouracil (5-FU) kills cells in gastrointestinal cancers by interfering with RNA synthesis, not by damaging DNA as previously thought. This finding suggests that combining 5-FU with RNA-targeting drugs could be more effective than current DNA-damaging combinations. The research may lead to new clinical trials aimed at enhancing 5-FU's effectiveness in treating colon and other GI cancers.

October 07, 2024
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