SMU defeated No. 22 Louisville 34-27, securing a comeback win and their third straight victory.

SMU defeated No. 22 Louisville 34-27, with quarterback Kevin Jennings achieving career highs of 281 passing yards and 113 rushing yards. Despite leading 24-13 at halftime, SMU faced a tie in the fourth quarter but secured the win after Jennings led a comeback drive, capped by an interception from Isaiah Nwokobia. This victory marks SMU's third straight win and positions them as contenders in the ACC, while Louisville faces potential rankings drop.