Researchers develop drug MED6-189 effective against drug-sensitive and resistant malaria parasites, disrupting apicoplast and vesicular trafficking pathways.
Researchers from UC Riverside, UC Irvine, and Yale have created a new drug, MED6-189, effective against both drug-sensitive and resistant strains of the malaria parasite Plasmodium falciparum. By disrupting the apicoplast and vesicular trafficking pathways in the parasite, the drug prevents resistance development. Promising results were seen in tests on humanized mice and monkeys. Further optimization and exploration of the drug's mechanisms are planned.
September 26, 2024
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