Human innate-like T cell development differs from mice, affecting immune capabilities and requiring consideration in immunotherapy development.

A study by Cold Spring Harbor Laboratory and the University of Colorado Anschutz found that innate-like T cells in humans develop differently than in mice, affecting their immune capabilities. In humans, these cells are less functional in early life but mature in adulthood. This research emphasizes the need to consider these differences when developing immunotherapies, as most preclinical tests use mouse models. The findings aim to enhance cancer treatment strategies.

September 24, 2024
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