18th-ranked Michigan defeated 11th-ranked USC 27-24, with Kalel Mullings scoring the game-winning touchdown in the Big Ten opener.

No. 18 Michigan defeated No. 11 USC 27-24 in a thrilling Big Ten opener, marked by Kalel Mullings' game-winning touchdown with 37 seconds left. Michigan overcame a 14-0 deficit and two second-half fumbles to extend their winning streak to a school-record 26 games. Despite a strong performance from USC's Miller Moss, who threw three touchdown passes, the Wolverines' defense ultimately secured the victory, impacting both teams' rankings in the AP Top 25.