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Researchers found sex-based differences in lung cancer immune responses, with CXCL13 prevalent in females and higher T-cell activation in female tumors.
Researchers at Saint Louis University School of Medicine have found significant sex-based differences in T-cell immune responses in lung cancer patients.
Their study revealed that the protein CXCL13, which indicates immunotherapy response, is more prevalent in females.
T-cells in female tumors showed high activation levels, while male tumors had more immune-suppressive T-cells.
These findings suggest the potential for tailored cancer treatments based on sex.
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Los investigadores encontraron diferencias basadas en el sexo en las respuestas inmunitarias al cáncer de pulmón, con CXCL13 prevalente en mujeres y mayor activación de células T en tumores femeninos.