Researchers at UC San Diego developed new methods to create stable circular RNA molecules, improving RNA therapy potential.

Researchers at the University of California San Diego have developed two new methods to create stable circular RNA (cRNA) molecules, which could lead to more effective and long-lasting RNA therapies. Circular RNAs, with a closed-loop structure, are more resistant to degradation than linear RNAs and were tested in heart muscle cells and neurons, displaying enhanced stability and biological activity. The new methods, involving RtcB protein or bacterial enzyme group II introns, are simpler and more scalable than previous methods, and future studies will investigate their application in other in vivo settings.

August 26, 2024
101 Articles

Further Reading