Australian researchers create cholesterol-based drug delivery system, enhancing parasite-treating drug effectiveness by 3-25 times.

Australian researchers from ANU have developed a cholesterol-based "Trojan horse" method that attaches cholesterol to drugs, exploiting parasites' need for cholesterol to survive. This allows the drugs to enter the parasite's system and exert their killing effect, making treatments for diseases like malaria, leishmaniasis, giardia, and livestock parasites 3-25 times more effective. This approach could also help repurpose redundant malaria drugs, save billions in agricultural losses, and provide new therapies for companion animals and livestock.

August 14, 2024
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