Researchers identify CAF subsets promoting lymphatic metastasis and reveal potential strategies to inhibit it.

Researchers from Sun Yat-sen Memorial Hospital published a study in Cancer Biology & Medicine, revealing CAFs' role in promoting lymphatic metastasis, a crucial factor in cancer progression. The study analyzed CAF subsets contributing to lymphatic invasion and metastasis through interactions with other stromal cells, cytokine secretion, and exosome production. By targeting specific CAF subsets, researchers demonstrated potential strategies to inhibit lymphatic metastasis and improve cancer treatments. The study emphasizes the importance of CAF heterogeneity in cancer progression and offers new avenues for designing targeted cancer therapies.

August 08, 2024
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