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Scientists sped up female iPSC production in mice with IFNγ, potentially improving disease modeling for XX individuals.
Scientists at the Centre for Genomic Regulation have discovered that adding interferon gamma (IFNγ) to mouse neural precursor cells can speed up the production of female induced pluripotent stem cells (iPSCs) by one day.
This could potentially improve disease modeling and drug testing for individuals with two X chromosomes, including women, transgender men, and men with Klinefelter syndrome.
The discovery also indicates that IFNγ makes X-chromosome reactivation more efficient, which could contribute to the field of personalized medicine for women.
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Los científicos aceleraron la producción de iPSC hembra en ratones con IFNγ, potencialmente mejorando el modelado de enfermedades para XX individuos.