UCLA and UPenn researchers create gene-isoform catalog in developing human brain, revealing insights into neurodevelopmental and psychiatric disorders.
Researchers from UCLA and the University of Pennsylvania have created a catalog of gene-isoform variation in the developing human brain, providing insights into the molecular basis of neurodevelopmental and psychiatric disorders. Utilizing third-generation long-read sequencing technologies, they discovered over 214,516 unique isoforms, with 70% previously unstudied. This comprehensive dataset may lead to targeted therapies, improved genetic diagnoses, and novel treatment approaches in gene therapy trials.
May 23, 2024
5 Articles