Baylor College of Medicine researchers discovered a non-hormonal, reversible male contraception approach using a small molecule that inhibits STK33 in mice.

Baylor College of Medicine researchers found a novel, non-hormonal sperm-specific approach for reversible human male contraception in a study published in Science. Identifying a small molecule that inhibits serine/threonine kinase 33 (STK33), the study showed in animal models that the inhibitor, CDD-2807, reduced fertility in male mice, with no toxicity, no accumulation in the brain, and reversible fertility recovery when treatment was discontinued. Further testing is needed to evaluate potential risks and long-term use.

May 23, 2024
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