15% of Alzheimer's cases linked to APOE4 homozygotes.

Researchers discovered a distinct genetic form of Alzheimer's disease linked to having two copies of the APOE4 gene (APOE4 homozygotes), affecting 95% of individuals over 65. This form, which causes earlier symptoms than others, may account for 15% of Alzheimer's cases. The findings, based on data from over 10,000 people and 3,000 brain donors, suggest that having two APOE4 copies could be a new genetic form of the disease, requiring specialized treatment and prevention strategies.

May 06, 2024
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