Columbia University researchers discover a gene mutation in FN1 that reduces Alzheimer's risk by 70% by preventing fibronectin build-up at the blood-brain barrier.
Columbia University researchers have discovered a gene mutation in the FN1 gene that reduces the risk of Alzheimer's disease by up to 70%. The "protective" variant in the FN1 gene, which codes for fibronectin, prevents excess fibronectin build-up at the blood-brain barrier, potentially offering a strong defense against Alzheimer's. The FN1 variant could lead to new therapies or drugs that mimic the gene's protective effect, targeting fibronectin to prevent or treat Alzheimer's disease.
April 10, 2024
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