6th-seeded Louisville women's basketball team lost to 11th-seed Middle Tennessee State, ending their 12-game first-round advance streak.

6th-seeded Louisville women's basketball team was defeated by 11th-seed Middle Tennessee State, ending the Cardinals' 12-game streak of advancing past the first round of the NCAA Tournament. Middle Tennessee staged a remarkable comeback, erasing an 18-point, second-quarter deficit to win 71-69 in the tournament's opening round. Savannah Wheeler scored 20 of her 22 points in the second half for Middle Tennessee.