Johns Hopkins researchers developed an algorithm, REAL-FAST, to identify high-risk precancerous lesions on fallopian tubes, linked to ovarian high-grade serous carcinoma.
Johns Hopkins researchers have developed an algorithm called REAL-FAST to identify high-risk precancerous lesions on fallopian tubes, known as serous tubal intraepithelial carcinomas (STICs). These lesions are believed to be the main precursors of ovarian high-grade serous carcinoma (HGSC), the most common type of ovarian cancer in women. The algorithm identified five distinct groups of precancerous lesions, two of which were found to be aggressive and often linked to recurrent HGSC, providing the first molecular evidence of unique identifiable genetic features in STICs.
March 06, 2024
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